Economic Evaluation

The social return on investment analysis addresses costs and benefits that are difficult to quantify, including community connectedness. Carers generally reported more problems on the EQ-5D-5L proxy than participants reported for themselves, except for self-care. The economic evaluation combines a within-trial cost-utility analysis with a model-based lifetime extrapolation. The review includes five established economic evaluation types. The base-case economic perspective is the National Health Service and personal social services. The review will assess whether digital health interventions are cost-effective compared with standard care, non-digital alternatives or other digital strategies. Usual care is the comparator for the economic evaluation. The base case economic analysis uses a public sector perspective aligned with NICE guidance. Incremental cost-effectiveness ratios will compare models. Most economic evaluations in tuberculosis diagnostics have focused on pulmonary TB rather than EPTB. The economic evaluation will account for intervention costs and possible cost offsets from reduced healthcare resource use. The intervention will be considered cost-effective under conditio…