eIF2α Phosphorylation
eIF2α phosphorylation is described as a core mechanism of the integrated stress response. Phosphorylated eIF2α inhibits eIF2B and reduces ternary complex formation. PERK, PKR, HRI, and GCN2 respond to distinct stress inputs that converge o…
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eIF2α phosphorylation is described as a core mechanism of the integrated stress response. Phosphorylated eIF2α inhibits eIF2B and reduces ternary complex formation. PERK, PKR, HRI, and GCN2 respond to distinct stress inputs that converge on eIF2α phosphorylation. eIF2α phosphorylation represses most translation but favors translation of regulatory mRNAs such as ATF4.