eIF4F/eIF4E Axis
During stress, mTORC1 inhibition causes 4EBP dephosphorylation, allowing 4EBP to bind eIF4E and repress cap-dependent translation. Under favorable conditions, mTORC1 phosphorylation of 4EBPs prevents 4EBPs from binding eIF4E and permits eI…
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During stress, mTORC1 inhibition causes 4EBP dephosphorylation, allowing 4EBP to bind eIF4E and repress cap-dependent translation. Under favorable conditions, mTORC1 phosphorylation of 4EBPs prevents 4EBPs from binding eIF4E and permits eIF4F assembly. The eIF4F/eIF4E axis is presented as a major initiation-control system during stress. Mnk1/Mnk2 phosphorylation of eIF4E is associated with selective translation of mRNAs linked to survival, angiogenesis, proliferation, tumor progression, and stress tolerance.