Electronic Patient-Reported Outcomes

Prior cancer trials have shown that ePRO monitoring can improve quality of life, physical function, symptom control, and overall survival. Routine symptom monitoring based mainly on outpatient clinician assessment can miss symptoms arising between visits. Direct evidence for ePRO monitoring in HCC patients receiving immunotherapy remains limited. ePRO-based monitoring can generate algorithm-driven alerts for clinicians or patients. ePRO-based monitoring collects patient-reported symptoms through digital devices during or between visits. The weekly survey was designed to balance clinical usefulness with participant burden.