Elephant Cancer Resistance
Elephants have 20 TP53 copies, whereas humans and many other mammals have one. Autopsy and database evidence cited in the article found cancer in about 4.8% of elephants, compared with human rates that can reach about 25%. Elephants are pr…
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Elephants have 20 TP53 copies, whereas humans and many other mammals have one. Autopsy and database evidence cited in the article found cancer in about 4.8% of elephants, compared with human rates that can reach about 25%. Elephants are presented as a natural example of cancer resistance despite their large size and long lifespan. LIF6 is proposed as a revived gene that helps protect elephants from cancer by responding to TP53 signaling.