End-Stage Kidney Disease

Early proteomic risk stratification enables therapeutic strategies to begin before substantial kidney function loss occurs. Early risk detection in APOL1 carriers with preserved kidney function is clinically significant because it precedes the damage that leads to ESKD. Therapeutic strategies for APOL1 high-risk individuals can be initiated before substantial kidney function loss, potentially preventing progression to ESKD. Early proteomic risk detection may enable intervention before substantial kidney function loss, potentially preventing or delaying ESKD. Early intervention strategies can begin before substantial kidney function loss, potentially delaying ESKD progression. Dietary approaches for kidney disease prevention and treatment are fundamentally different. Large cohort studies have quantified the risk of progression to ESKD across populations with high-risk APOL1 genotypes. Large cohort studies have quantified the risk of ESKD progression across populations carrying high-risk APOL1 genotypes. Large cohort studies quantified ESKD progression risk across populations carrying APOL1 variants. Large cohort studies have quantified ESKD progression risk across populations carry…