Endocannabinoid System

Cannabis dosing and product selection are described as unresolved and highly patient-specific. The article explains variation in cannabis response through individual differences in the endocannabinoid system. The endocannabinoid system is described as influencing pain, appetite, nausea, mood, inflammation, and other physiological processes. Food intake, timing, delivery form, and physiology can change a person’s response to cannabis. The endocannabinoid system contributes to homeostasis across brain and body systems, and Δ9-THC interacts with it directly. Cannabinoid receptor 1 and cannabinoid receptor 2 are distributed throughout the body and are both present in lung tissue. Studies suggest Δ9-THC may produce transient bronchodilation and reduce inflammatory responses in the pulmonary system.