Endothelial Permeability Mechanisms

Hantavirus infection can impair endothelial barrier function without necessarily destroying endothelial cells outright. Pathogenic hantaviruses may increase endothelial responsiveness to VEGF, weakening junction control and promoting plasma leakage. CD8 T-cell responses and inflammatory mediators may worsen pulmonary or cardiopulmonary injury. Bradykinin pathways are presented as a research target because they may affect vascular permeability and fluid leakage.