Endotoxins

The Hetox trial reports improvements in endotoxins and several metabolic markers. Polyphenol-rich foods and antioxidants are presented as potentially reducing meal-related endotoxemia. A spore probiotic is described as complementary to B. longum 1714 because it targets LPS translocation and barrier function. The Hetox clinical data are limited by missing baseline values, absolute changes, confidence intervals, adverse events, and publication details. Reduced endotoxin levels are used as a major marker of improved gut-liver and systemic status in the Hetox discussion. The article notes that downstream endotoxin effects are presented mechanistically with varying causal strength. Endotoxins have been found within arterial plaques during calcium scoring evaluations. The systemic inflammatory cascade caused by endotoxemia is largely unrecognized by conventional medicine. Endotoxemia is defined as the entry of lipopolysaccharide (LPS) from bacterial breakdown products into the bloodstream. When systemic tolerance fails, LPS enters circulation and triggers chronic low-grade systemic inflammation called metabolic endotoxemia. The article states that increased intestinal permeability allow…