Episodic Memory

A 22% increase in mean PROMEA total score at 3 months is defined as a clinically significant treatment response. Long-term visual episodic memory is a hippocampus-dependent function that is commonly impaired in Down syndrome. The primary outcome is improvement in the PROMEA visual object learning test, assessed after 3 months of treatment. Secondary memory outcomes include visual-spatial learning, verbal learning, associative memory, and a parent-completed observer memory questionnaire. The processing dissociation procedure is designed for people with intellectual disability and estimates the separate contributions of recollection and familiarity.