Estrobolome

The estrobolome is the gut microbiome subset that metabolizes and regulates circulating estrogen. Beta-glucuronidase activity is presented as a clinical marker of estrogen recycling dynamics. Beta-glucuronidase deconjugates estrogen marked for excretion, enabling reabsorption into systemic circulation. The estrobolome determines whether estrogen delivered to the intestinal tract is excreted or recycled into circulation. The estrobolome consists of gut microbes that produce beta-glucuronidase and regulate estrogen metabolism. The estrobolome is the community of gut microbiota that metabolizes estrogens, and estrogen loss during menopause causes dramatic loss of gut microbiome diversity. Constipation can worsen estrobolome dysfunction by increasing the time estrogen remains in contact with intestinal mucosa. Beta-glucuronidase releases conjugated estrogen back into circulation. Declining estradiol degrades tight junction integrity, increasing intestinal permeability and fueling systemic chronic inflammation. Estrogen loss shifts the gut microbiome from a female-patterned community toward an androgenic profile associated with male physiology. Reduced ER Alpha activity from estrogen d…