EVD-Associated Uveitis

The case definition for EVD-associated uveitis requires current or prior uveitis or sequelae with symptoms or vision loss during or after EBOV infection and not attributable to other causes. Across cohort studies, uveitis prevalence in EVD survivors ranged from 13% to 34%, compared with about 1% in controls. The PREVAIL Study in Liberia found higher uveitis prevalence in EVD survivors than in close-contact controls. Infectious EBOV was detected in aqueous humour after acute viremia had cleared in a convalescent survivor with severe panuveitis. The article frames ocular immune privilege as a setting where EBOV can persist and drive vision-threatening inflammation after acute infection. Uveitis is the most common ocular complication of Ebola virus disease.