Excitatory Amino Acid Inhibitors

The review does not establish EAA inhibitors as effective acute neuroprotective therapy for moderate to severe TBI. The clinical evidence base included NMDA-targeting ionotropic glutamate receptor antagonists and magnesium sulfate, while other EAA inhibitor classes have not yet been evaluated in humans with TBI. Nine EAA inhibitors were evaluated in the included trials. EAA inhibitors are not currently guideline-recommended for acute moderate to severe TBI because clinical evidence has been mixed. Early EAA inhibitor use was evaluated as an acute treatment for adults with moderate to severe traumatic brain injury.