Familial Hypercholesterolemia

Current dietary guidelines for managing coronary disease in FH are based on outdated and unsupported information. Approximately 85% of people with the FH genetic predisposition are unaware they have it. Familial hypercholesterolemia affects approximately 1 in 500 people, meaning the vast majority of people with elevated cholesterol do not have this condition. Familial hypercholesterolemia is a genetic condition causing approximately 50% fewer LDL receptors, leading to LDL buildup in the bloodstream regardless of diet. Familial hypercholesterolemia is a genetic defect that prevents the liver from reabsorbing and regulating LDL, causing levels to escalate without a natural ceiling. Individuals with familial hypercholesterolemia face meaningfully shortened lifespan and warrant medical intervention. People with FH who follow low-fat, low-cholesterol diets still carry a significantly elevated risk of dying from a heart attack. Xanthomas and arcus senilis are physical signs that may indicate FH before a formal diagnosis.