Fragile Breakage Model

FBM is represented as a special case of TFBM with no turnover of fragile regions. FBM predicts similar scaled reuse across branch distances, unlike the real mammalian data described in the article. Pairwise human-mouse analyses showed extensive breakpoint reuse that supported the Fragile Breakage Model. The Fragile Breakage Model proposes that mammalian genomes contain solid and fragile regions, with rearrangements concentrated in the fragile subset. Under FBM, breakpoint reuse depends on branch length but not phylogenetic distance.