Frailty

Participants reportedly improved after culture-expanded stem cells, but the article frames this as a study example rather than broad proof. The study classified participants as frail if they met three frailty criteria and as prefrail if they met one or two criteria. Frailty was most prevalent among patients with dementia, affecting 94% of that subgroup. 46% of the hospitalised cohort was classified as frail, which is higher than community estimates but consistent with Australian inpatient estimates. Frailty was substantially more common among AS patients than controls. Frailty is presented as a predictor of ICU outcomes beyond chronological age. Frailty is one of the three most prevalent and clinically significant geriatric syndromes. Frailty categorical status did not differ significantly between participants with efficient and inefficient sleep. Physical frailty measures often improve after kidney transplant despite frailty being common in kidney failure. Frailty may better capture physiological vulnerability to medicines than age alone. The central hypothesis is that frailty secondary to kidney failure and age-related frailty may share similar physiological and molecular featur…