Framework Limitations
The framework does not report a new empirical cohort or prospective validation of the prognostic score. The optimality theorem depends on restrictive assumptions that may not hold for many clinical biomarkers. High-dimensional settings wit…
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The framework does not report a new empirical cohort or prospective validation of the prognostic score. The optimality theorem depends on restrictive assumptions that may not hold for many clinical biomarkers. High-dimensional settings with more biomarkers than samples create rank deficiency in the Hamiltonian. The formalism is currently static and would need time-varying Hamiltonians for longitudinal disease progression.