Functional Enrichment

Functional enrichment results nominate biological processes but do not experimentally validate gene function, methylation causality, or clinical utility. Classical functional enrichment emphasized neuronal and synaptic biology. KEGG enrichment included neuroactive ligand signaling, cAMP signaling, glutamatergic synapse, axon guidance, hormone signaling, and cell adhesion molecule interaction. GO biological process enrichment included chemical synaptic transmission, synapse assembly, glutamatergic synaptic transmission, axon guidance, and MAPK cascade regulation.