Gene Network Stability
The model predicts larger lifespan effects from changing the stability exponent than from lowering stress alone. The stability condition depends on the ratio of regulatory defect propagation to repair and turnover capacity. The model treat…
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The model predicts larger lifespan effects from changing the stability exponent than from lowering stress alone. The stability condition depends on the ratio of regulatory defect propagation to repair and turnover capacity. The model treats aging as accumulation of epigenetic or regulatory errors in a genetic network. Ordinary aging is interpreted as instability in coupled genome-expressome regulatory networks.