Genetic Predisposition to Inflammation

Natural forms of folate, B12, choline, and B1 are required to properly support gene function and reduce inflammation; synthetic forms are inferior. Those with confirmed genetic inflammatory variants may need higher doses and longer durations of anti-inflammatory interventions. Impaired methylation is a specific genetic vulnerability that leads to increased inflammation, impaired detoxification, and potentially depression. Research has identified specific gene variants that make some individuals substantially more prone to inflammation and pain when exposed to triggers.