Genetic Toggle Switch

The toggle switch is simple but highly sensitive to parameter and stochastic perturbations. The circuit contains two mutually inhibitory repressors in the absence of external inducers. The genetic toggle switch can exhibit bistability and…

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The toggle switch is simple but highly sensitive to parameter and stochastic perturbations. The circuit contains two mutually inhibitory repressors in the absence of external inducers. The genetic toggle switch can exhibit bistability and operate as a molecular logic element. The genetic toggle switch is used as the article's benchmark two-gene regulatory circuit.