Genomic Integration
The case shows that generally non-integrating vector systems can still integrate in rare circumstances. A rare case linked genomic integration of an AAV gene therapy vector to tumor development. AAV integration can occur even though AAV ve…
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The case shows that generally non-integrating vector systems can still integrate in rare circumstances. A rare case linked genomic integration of an AAV gene therapy vector to tumor development. AAV integration can occur even though AAV vectors are generally considered non-integrating. The reported case involved rare genomic integration of an adenovirus-associated vector linked to tumor formation.