Gut Lining Damage

Celiac disease is an autoimmune reaction to gluten that destroys intestinal villi, the absorptive surface of the small intestine. Any condition that damages the intestinal lining compromises nutrient absorption across the board. Cystic fibrosis severely impairs both pancreatic enzyme secretion and intestinal fat absorption, beyond its well-known pulmonary effects. A disrupted gut microbiome reduces bile recycling efficiency, forcing the liver to synthesize more bile from scratch; probiotic supplementation helps restore this recycling.