Haemoglobinopathy Screening

The device had prior validation against reference methods including HPLC and haemoglobin electrophoresis. The Gazelle device separates haemoglobin types by charge using electrophoresis principles. The study used the Gazelle Hb variant point-of-care device for haemoglobinopathy screening. Point-of-care testing without confirmatory laboratory methods may have allowed misclassification of haemoglobin variants. Screening programmes should be expanded in tribal regions for early detection and timely management. The device outputs were interpreted to identify conditions including sickle cell disease, sickle cell trait, beta-thalassaemia major, and beta-thalassaemia minor.