Hamilton Depression Scale

The UK requires a minimum three-point improvement on the Hamilton scale for clinical significance, a threshold the United States does not apply. The Hamilton Depression Scale is the gold standard for measuring depression in clinical trials…

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The UK requires a minimum three-point improvement on the Hamilton scale for clinical significance, a threshold the United States does not apply. The Hamilton Depression Scale is the gold standard for measuring depression in clinical trials despite never being designed for diagnostic use. The Hamilton Depression Scale relies on physician observation rather than objective markers or patient self-report.