Hard Lesions

Type 1 diabetes is presented as a hard lesion because insulin-producing beta cells have been destroyed. Alzheimer's disease is presented as the hard-lesion endpoint of brain degeneration because many brain cells have been destroyed. A hard lesion is defined as a complete and typically irreversible loss of function. In neurology, a hard lesion means the pathway from brain to limb is completely severed and will not return. A heart attack is described as a hard-lesion transition where cardiac muscle cells die because blood and oxygen delivery becomes too low.