Hepatic Outcomes

Sepsis or septic shock was lower with liberal transfusion, but certainty was low. Acceptability is treated as a primary endpoint because withdrawal reflects safety, tolerability, and partly efficacy. The safety of liberal transfusion cannot be fully characterized because certainty was low to very low and some adverse events were underreported. No significant differences were found for mortality or most specified adverse events. Safety outcomes included transfusion-related lung injury, circulatory overload, ARDS, infections, thromboembolic events, myocardial infarction, and intracranial hypertension.