High-Fat Diet Research

A 40% fat, 20% protein, 40% carbohydrate diet is not considered high fat or low carb by the article's functional definition. The high-fat, high-carb combination used in mouse studies produces metabolic dysfunction and obesity, confirming that co-presence of carbohydrates drives fat storage. The article argues that some studies mislabel diets as high-fat and low-carb when they use about 40% carbohydrate. These mouse studies do not model ketogenic eating and are not applicable to low-carb, high-fat dietary approaches. Studies claiming high-fat diets cause obesity use experimental diets that are also high in carbohydrates, around 36%. Adding high fat to a high-insulin state leads dietary fat to be stored rather than burned, according to the article. The article says harmful outcomes in these studies are caused by carbohydrate-driven insulin rather than fat itself. The article warns insulin-resistant people not to combine high fat and high carbohydrate intake. For insulin-resistant people, 40% of calories from carbohydrate is presented as enough to keep insulin chronically elevated.