Histamine Sensitivity

Post-meal histamine fatigue is distinct from ordinary post-meal tiredness in that it is a sharp, noticeable drop. Genetic testing including the DAO gene can confirm predisposition to histamine sensitivity. Histamine is a neurotransmitter and immune mediator that activates the nervous system. Gut dysbiosis, particularly SIBO, can cause bacteria to overproduce histamine while insufficient DAO enzyme activity prevents adequate breakdown. A clear post-meal energy drop pattern indicates histamine reaction rather than unrelated fatigue. Itching or hives after eating eggs, fermented foods, alcohol, or aged cheeses are clues that histamine sensitivity may be contributing to migraines. A low-histamine diet, quercetin supplementation, Cromolyn taken orally, and gut microbiome repair can produce significant improvement in histamine-sensitive migraineurs.