Hit-and-Run Dosing

Senolytics are not intended to be taken continuously in the article's framework. The hit-and-run model uses brief exposure to senolytic compounds followed by time for repair and new cell growth before repeating. The source argues that senolytic cycles should be spaced far enough apart to allow replacement and repair. The discussed natural senolytic stack is described as taken for two consecutive days per month. Too-frequent senolytic use is presented as theoretically undesirable because it may stress regeneration and progenitor or stem-cell pools.