Homocysteine and MTHFR

The MTHFR genetic variant impairs conversion of synthetic B vitamins to bioavailable forms, causing homocysteine to accumulate even in people consuming fortified foods. B12 should be consumed as methylcobalamin rather than cyanocobalamin to ensure bioavailability. Elevated homocysteine damages the arterial lining and significantly raises the risk of heart attack and stroke. Folic acid is a synthetic form of B9 added to enriched flour, energy drinks, and most supplements that many people cannot convert to the active form. Natural folate from food sources such as greens, liver, and nutritional yeast is the correct form of B9, as opposed to synthetic folic acid.