HUA–HTN Comorbidity

Existing research on HUA+HTN comorbidity in Chinese children and adolescents is limited by regional constraints, small sample sizes, inconsistent age stratification, and incompatible diagnostic criteria. When HUA and HTN co-occur, their combined cardiovascular and cerebrovascular harm exceeds the sum of either condition acting alone. The HUA+HTN comorbidity markedly elevates risk of stroke, ischaemic heart disease, myocardial hypertrophy, and left ventricular diastolic dysfunction. Cardiovascular diseases arising in childhood or adolescence frequently persist into adulthood, making the current paediatric comorbidity burden a long-term public health concern. In adolescent populations, the comorbidity can cause subclinical damage including microangiopathy, premature arteriosclerosis, and declined glomerular filtration function, raising the probability of adult chronic cardiorenal disease.