Human Genome Evolution
Closer evolutionary comparisons predicted human-lineage rearrangements better than more distant comparisons. Mouse versus the human-macaque ancestor produced 552 breakpoints, of which 34 were used in the human lineage. Macaque-QH breakpoin…
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Closer evolutionary comparisons predicted human-lineage rearrangements better than more distant comparisons. Mouse versus the human-macaque ancestor produced 552 breakpoints, of which 34 were used in the human lineage. Macaque-QH breakpoints predicted human-lineage breakpoints with about 16% accuracy. Recently affected breakpoint regions on H+, Q+, and QH+ are proposed as the best proxy for currently active fragile regions in the human genome. Breakpoints reused in recent primate lineages are proposed as candidate sites of future rearrangements in human genome evolution.