Human-Mouse Comparison
Human ncRNA length was reported as 650,012,775 bp, compared with 243,294,640 bp in mouse. Humans had more ncRNA genes than mice, whereas mice had more protein-coding genes than humans. Human noncoding regions contained more GGTGCG and CGTA…
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Human ncRNA length was reported as 650,012,775 bp, compared with 243,294,640 bp in mouse. Humans had more ncRNA genes than mice, whereas mice had more protein-coding genes than humans. Human noncoding regions contained more GGTGCG and CGTATA than mouse noncoding regions, while mouse noncoding regions contained more TCTCTC. Protein-coding length differed less strongly between humans and mice than ncRNA length did. The study used humans and mice as a focused evolutionary contrast because their lifespans differ substantially. The paper argues that human lifespan evolution involved accumulation of long-life motifs and reduction of short-life motifs.