Hypothalamic Inflammation

The article does not specify a standardized clinical protocol for measuring or treating hypothalamic inflammation. The hypothalamus helps regulate appetite, energy expenditure, body temperature, sleep, stress hormones, and metabolic rate. Hypothalamic inflammation can contribute to insulin resistance and excess body fat. Inflammation can impair hypothalamic function and disorganize metabolic regulation. The inflammation-insulin resistance-body fat loop is offered as a reason calorie restriction alone may not work for some people. Neural inflammation, especially hypothalamic inflammation, is presented as a major catalyst in obesity.