ICU-Acquired Weakness

ICU-acquired weakness is described as the primary driver of physical impairments within post-intensive care syndrome. ICU-acquired weakness arises from interactions among inflammation, immobilisation, ventilation, sedation, and underlying illness. ICU-acquired weakness may involve critical illness polyneuropathy, critical illness myopathy, or both. ICU-acquired weakness is associated with prolonged ventilation, delayed recovery, longer hospital stay, and higher mortality. ICU-acquired weakness causes diffuse skeletal muscle weakness in about 43% of adults requiring critical care.