IGF-1R

Targeting IGF-1R has inhibited Ewing sarcoma cell growth in vitro and in xenograft models. IGF-1R inhibition alone has produced low clinical response rates. IGF-1R activates downstream oncogenic pathways including PI3K, Akt, and mTOR. IGF-…

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Targeting IGF-1R has inhibited Ewing sarcoma cell growth in vitro and in xenograft models. IGF-1R inhibition alone has produced low clinical response rates. IGF-1R activates downstream oncogenic pathways including PI3K, Akt, and mTOR. IGF-1R has a documented role in Ewing sarcoma.