Immunophenotype
CD4-dominant phenotype was more common in geriatric patients, while CD8-positive/CD4-negative phenotype was more common in non-geriatric patients. Immunohistochemical findings were extracted from existing pathology reports rather than gene…
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CD4-dominant phenotype was more common in geriatric patients, while CD8-positive/CD4-negative phenotype was more common in non-geriatric patients. Immunohistochemical findings were extracted from existing pathology reports rather than generated through new staining or centralized review. Reported immunophenotype frequencies may reflect documentation practices and evolving IHC panels as well as underlying biology. Classic mycosis fungoides is usually composed of CD3-positive, CD4-positive, CD45RO-positive memory T cells with relative reduction in CD8-positive T cells. Higher CD4 dominance in older patients may be related to immunosenescence.