Inflammaging

Women demonstrate a later but stronger rise in IL-6 than men as hormones change. Depression is associated with elevated pro-inflammatory markers including IL-6, placing it in the same inflammatory category as menopause, obesity, and autoimmune disease. Inflammaging is defined as chronic age-associated inflammation linked to multiple aging-related diseases. Inflammaging is persistent low-grade sterile inflammation rather than normal acute repair inflammation. Inflammaging is described as a chronic, low-grade inflammatory state that develops with biological aging. Senescent cells are described as persistent cells that release inflammatory signals into tissue and blood. Inflammaging is a chronic, low-grade inflammatory state that develops as the immune system ages and dysregulates. Inflammaging promotes collagen and elastin breakdown through matrix metalloproteinases. Inflammaging is presented as multifactorial rather than a single-cause phenomenon. During aging, the innate immune system becomes hyperresponsive and sustains background activation. Inflammaging is presented as mechanistically central to major chronic diseases of aging. Mast cell activation is hypothesized as a possible…