Insulin Management

Participants with screening HbA1c from 7.0% to below 8.0% receive about a 10% reduction in total daily insulin dose before randomisation. Participants with screening HbA1c above 8.0% receive no initial insulin adjustment. DAFNE training is considered important because it teaches safe insulin adjustment during illness and when starting treatments such as tirzepatide. Hypoglycaemia and diabetic ketoacidosis are major safety concerns in type 1 diabetes if insulin is reduced too aggressively during tirzepatide treatment.