Intracranial Pressure

EAA inhibitors did not significantly change mean ICP compared with control. Mean intracranial pressure was assessed as a secondary outcome. Six trials with 924 patients contributed to the mean ICP analysis. Trial sequential analysis crosse…

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EAA inhibitors did not significantly change mean ICP compared with control. Mean intracranial pressure was assessed as a secondary outcome. Six trials with 924 patients contributed to the mean ICP analysis. Trial sequential analysis crossed the futility boundary for mean ICP. Impaired blood flow out of the brain can cause pressure to build inside the skull. High intracranial pressure was identified as the likely source of the piercing nighttime headaches. High intracranial pressure places harmful pressure on the brain.