Keystone Microbes

Keystone microbe elimination cascades through the entire gut ecosystem and creates vulnerability to inflammatory, autoimmune, and metabolic disease. Akkermansia muciniphila is deficient in 40–60% of the population and maintains the mucosal barrier against pathogens while protecting against metabolic syndrome and obesity. Faecalibacterium prausnitzii is deficient in 30–50% of the population and its loss reduces inflammation suppression and autoimmune protection. The absence of Ruminococcus — deficient in 50–60% of the population — explains why many people cannot tolerate vegetables and experience symptom relief on a carnivore diet. Prevotella is deficient in 70–80% of the population; its loss impairs blood sugar balance and oxalate clearance, raising kidney stone risk.