Labile Iron
Labile iron is the redox-active, weakly chelated iron fraction most relevant to oxidative injury. Excess labile iron can generate hydroxyl radicals and reactive oxygen species through Fenton and Haber-Weiss reactions. During severe sepsis…
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Labile iron is the redox-active, weakly chelated iron fraction most relevant to oxidative injury. Excess labile iron can generate hydroxyl radicals and reactive oxygen species through Fenton and Haber-Weiss reactions. During severe sepsis and septic shock, protective iron-sequestering mechanisms can be overwhelmed. Oxidative damage from labile iron is presented as contributing to systemic inflammation, multiorgan dysfunction, and acute kidney injury.