Lactic Acidosis

B1 deficiency and metformin use are two of the most common and underrecognized triggers of lactic acidosis. Lactic acidosis in the legs results from two converging factors: a diet high in carbohydrates and sugar, and a severe deficiency of vitamin B1. Lactic acidosis is a condition where the body's pH becomes excessively acidic because sugar cannot be properly metabolized. Higher carbohydrate consumption increases the body's demand for vitamin B1, and when B1 cannot keep pace, lactic acid builds up and oxygen delivery to leg tissue is impaired. When vitamin B1 is insufficient, the body accumulates lactate, blood pH drops, and CO2 is retained, all of which severely impair oxygen uptake and create labored breathing. Thiamine depletion from alcohol consumption increases the risk of lactic acidosis. Metformin use is a known cause of lactic acidosis. Severe biotin deficiency can cause lactic acidosis. Vitamin B1 is the primary remedy for lactic acidosis. The primary symptom of leg lactic acidosis is extreme nighttime restlessness with an unbearable urge to move.