LDL Particle Quality
Cardiovascular risk from LDL is determined by particle size and density rather than total LDL quantity alone. Poor cholesterol quality is not defined by a high LDL number but by high triglycerides, low HDL, and predominance of small dense…
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Cardiovascular risk from LDL is determined by particle size and density rather than total LDL quantity alone. Poor cholesterol quality is not defined by a high LDL number but by high triglycerides, low HDL, and predominance of small dense LDL. The pattern of high triglycerides, low HDL, and small dense LDL is strongly associated with insulin resistance and metabolic dysfunction. Small, dense LDL particles oxidize more readily and penetrate the endothelium more easily than large, buoyant LDL.