Left Ventricular Remodeling

LVEDV/BSA was larger in higher echocardiographic grades. Existing post-MI therapies mostly reduce neurohormonal activation and hemodynamic load rather than directly targeting myocardial maladaptation. Cardiac remodeling was defined as increased LVEDV indexed to body surface area. Many trial participants had not yet developed advanced ventricular remodeling at randomization. Early enrollment after myocardial infarction may have limited the ability to detect reverse remodeling. More prolonged CDR132L exposure may be needed for maximal remodeling effects based on preclinical data. Adverse remodeling after myocardial infarction links myocardial injury to progressive heart failure and death. Adverse remodeling includes ventricular dilation, hypertrophy, fibrosis, impaired contractility, and worsening systolic function. Admission echocardiographic abnormalities may reflect early remodeling involving structural dilation and functional consequences. Left ventricular dilatation after infarction predicts long-term outcomes.