Lifespan-Associated Motifs

GGTGCG and CGTATA were classified as long-life motifs because their coefficients were positive. ACGTCG and TCTCTC were classified as short-life motifs because their coefficients were negative. The motif heatmap showed GGTGCG and CGTATA increasing as lifespan increased, while ACGTCG and TCTCTC decreased with longer lifespan. FINET selected four motifs with frequency scores above 0.6. Regression analysis showed significant positive motif-lifespan relationships for GGTGCG and CGTATA. ACGTCG did not show a significant association with lifespan in the reported regression. The motif discovery procedure generated all possible DNA motifs of length 1 through 7, producing 22,868 candidates.