Lifespan Reduction
Total lifespan reduction showed the opposite age pattern from acute mortality, with the highest losses for younger onset ages. For young onset ages, lifetime years lost were more than 100 times deaths during disease alone. Observation wind…
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Total lifespan reduction showed the opposite age pattern from acute mortality, with the highest losses for younger onset ages. For young onset ages, lifetime years lost were more than 100 times deaths during disease alone. Observation windows longer than roughly 20 years were needed before the modeled peak impact shifted away from the oldest ages. The phenomenological model predicted that long-term post-survivor lifespan loss is largest at young onset ages because baseline frailty increases with age. Lifetime disease impact cannot be inferred from acute fatality alone.