Lipid-Lowering Therapy
Moderate-intensity statins reduce LDL-C by about 30%, while high-intensity statins reduce LDL-C by about 50%. The GDMT control arm uses a stepwise lipid management approach consistent with major US and Chinese ACS lipid guidance. REPRESS u…
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Moderate-intensity statins reduce LDL-C by about 30%, while high-intensity statins reduce LDL-C by about 50%. The GDMT control arm uses a stepwise lipid management approach consistent with major US and Chinese ACS lipid guidance. REPRESS uses moderate-intensity rather than high-intensity statins in comparison with several prior PCSK9 plaque studies. Traditional stepwise lipid-lowering escalation can take up to 3 months to reach LDL-C goals, overlapping with the highest recurrent-event risk period after ACS. The strike-early-and-strong strategy aims for rapid LDL-C reduction immediately after ACS.