Liver De Novo Lipogenesis

De novo lipogenesis is the liver process that converts dietary sugars and carbohydrates into triglycerides. The liver packages triglycerides produced through de novo lipogenesis into VLDL particles. Portal vein endotoxemia from SIBO stimulates the liver to increase de novo lipogenesis. Diet, gut-derived endotoxin, liver fat production, visceral fat, insulin resistance, and inflammation create a self-reinforcing vicious cycle. De novo lipogenesis is the central pathway connecting carbohydrate intake to small dense LDL formation and coronary disease risk. Dietary sugars and starches, rather than saturated fat alone, are placed at the start of the coronary disease risk-producing chain.